Combination syk kinase inhibitor and antihistamine for allergic conjunctivitis
IC 270 is a SYK kinase inhibitor combined with a commercially available antihistamine to treat acute and chronic allergic conjunctivitis, inflammatory condition of the eye due to exposure to pollen or mold. It has the potential to be a leading allergy medicine that can alleviate itch, redness, and the inflammatory effect associated with an allergic response.
The ability to treat itch as well as redness/inflammation could make IC 270 the first-in-class ocular allergy combination product
Since the SYK kinase activation is the first step in the cascade leading to histamine release, there is the potential that SYK kinase inhibition may have an additive or synergistic effect with the antihistamine in reducing itch when IC 270 is administered in a chronic allergy setting